A Review of Important Discontinuous B-Cell Epitope Prediction Tools
نویسندگان
چکیده
منابع مشابه
Bioinformatics Resources and Tools for Conformational B-Cell Epitope Prediction
Identification of epitopes which invoke strong humoral responses is an essential issue in the field of immunology. Localizing epitopes by experimental methods is expensive in terms of time, cost, and effort; therefore, computational methods feature for its low cost and high speed was employed to predict B-cell epitopes. In this paper, we review the recent advance of bioinformatics resources and...
متن کاملB-cell Epitope Prediction
When a living organism encounters a pathogenic virus ormicrobe, the B cells of the immune system recognize the pathogen’s antigens by their membrane-bound immunoglobulin receptors and, in response, produce antibodies specific to these antigens. The term antigen refers to any entity—a cell, a macromolecular assembly, or a molecule—that may be bound by either a B-cell receptor or an antibody mole...
متن کاملPEPITO: improved discontinuous B-cell epitope prediction using multiple distance thresholds and half sphere exposure
MOTIVATION Accurate prediction of B-cell epitopes is an important goal of computational immunology. Up to 90% of B-cell epitopes are discontinuous in nature, yet most predictors focus on linear epitopes. Even when the tertiary structure of the antigen is available, the accurate prediction of B-cell epitopes remains challenging. RESULTS Our predictor, PEPITO, uses a combination of amino-acid p...
متن کاملTowards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools.
A B-cell epitope is the three-dimensional structure within an antigen that can be bound to the variable region of an antibody. The prediction of B-cell epitopes is highly desirable for various immunological applications, but has presented a set of unique challenges to the bioinformatics and immunology communities. Improving the accuracy of B-cell epitope prediction methods depends on a communit...
متن کاملDiscontinuous epitope prediction based on mimotope analysis
MOTIVATION Phage display is a widespread technique used to obtain peptide mimotopes selected by binding to a given monoclonal antibody in a similar way as the native epitope. However, the localization of the interaction site mimicked by the mimotopes on the surface of the antigen is not always a straightforward task. MIMOP is a computational tool developed with the aim of helping experimentalis...
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ژورنال
عنوان ژورنال: Journal of Clinical & Cellular Immunology
سال: 2015
ISSN: 2155-9899
DOI: 10.4172/2155-9899.1000358